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Synthesis 1990; 1990(4): 357-360
DOI: 10.1055/s-1990-26877
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Einführung von Aminogruppen in Nachbarstellung zu Trifluormethylgruppen in Heterocyclen; Synthese von 5-Amino-4-trifluormethylthiazolen

Klaus Burger* , Eva Höß, Klaus Geith
  • *Institut für Organische Chemie der Technischen Universität München, Lichtenbergstraße 4, D-8046 Garching bei München, Federal Republic of Germany
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Publication Date:
17 September 2002 (online)

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Introduction of Amino Groups Adjacent to Trifluoromethyl Groups in Heterocyclic Compounds; Synthesis of 5-Amino-4-trifluoromethylthiazoles On reaction of 5-fluoro-4-trifluoromethylthiazoles 5 with primary aromatic and heteroaromatic amines, in the presence of 4-dimethylaminopyridine, a transamination process occurs to yield 5-amino-4-trifluoromethylthiazoles 2. Likewise, compounds 2 are formed in excellent yields on reaction of 5-azido-4-trifluoromethylthiazoles 1 with certain enamines.