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Synthesis 1990; 1990(6): 465-466
DOI: 10.1055/s-1990-26905
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Synthesis of α-CH2-X Functionalized Tryptophan Methyl Ester

Dagmar Pettig* , David C. Horwell
  • *Parke-Davis Research Unit, Addenbrookes Hospital Site, Hills Road, Cambridge, CB2 2QB, England
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Publikationsdatum:
17. September 2002 (online)

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A short and efficient synthesis of α-CH2-X functionalized tryptophan methyl ester (methyl 2-amino-3-(1H-indol-3-yl)propionate) is described, by alkylation of methyl 2-isocyano-3-(1H-indol-3-yl)propionate with a range of functionalized alkyl halides.

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