Preparation of N 1,N 2,N 2-Trisubstituted N 1-Acylamidinium Salts from Nitrilium Salts and N,N-Disubstituted Amides
17 September 2002 (online)
Nitrilium salts (1) react with N,N-disubstituted amides (2) furnishing N 1,N 2,N 2-trisubstituted N 1-acylamidinium salts (4). These salts are effective substrates with the N 1-acyl residue as leaving group for nucleophilic substitutions. Reactions with the nucleophiles methanol, and imines (6) are described.