Synthesis 1990; 1990(6): 530
DOI: 10.1055/s-1990-26930
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A New Synthesis of γ-Substituted α-Methylene-γ-butyrolactones (2-Methylene-4-alkanolides) using Catalysis by SnCI2/Amberlyst 15

Patrice Talaga* , Marcel Schaeffer, Claude Benezra, Jean-Luc Stampf
  • *Laboratoire de Dermatochimie, Associé au CNRS, Université Louis Pasteur Clinique Dermatologique, CHU, F-67091 Strasbourg, France
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Publication History

Publication Date:
17 September 2002 (online)

Reaction of α-bromomethylacrylic acid with aldehydes or ketones in an SnCl2/amberlyst 15/THF/H2O system affords 2-methylene-4-alkanolides in mostly good yields.