Synthesis 1990; 1990(7): 628-630
DOI: 10.1055/s-1990-26963
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Convenient Syntheses of 1,3-Dihydro-1-oxo-4-isobenzofurancarboxylic Acid, 1,3-Dihydro-3-oxo-4-isobenzofurancarboxylic Acid, and the Homologous Acetic Acids

Richard W. Skeean* , O. P. Goel
  • *Parke-Davis Pharmaceutical Research Division, Warner-Lambert, Company, Ann Arbor, MI 48105, USA
Further Information

Publication History

Publication Date:
17 September 2002 (online)

1-Dihydro-1-oxo- and 1,3-dihydro-3-oxo-4-isobenzofurancarboxylic acids were prepared in good yield by extensions of the Davies and Perkin synthesis of phthalide and were homologated to the corresponding acetic acid derivatives via the Arndt-Eistert reaction.