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Synthesis 1990; 1990(8): 691-693
DOI: 10.1055/s-1990-26983
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Scope and Limitations of Oxidative Decarboxylation of α-(Acylamino) Acids by Peroxy Acids: Conversion of a 2-Azetidinone-4-carboxylic Acid to a Carbapenem

Masao Shiozaki*
  • *New Lead Research Laboratories, Sankyo Co., Ltd., Hiromachi 1-2-58, Shinagawa-ku, Tokyo 140, Japan
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Publication Date:
17 September 2002 (online)

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Oxidative decarboxylation of α-(acylamino) acids by peroxy acids was investigated. An application of this reaction for the conversion of the 2-azetidinone-4-carboxylic acid 1h to a carbapenem 8 is described.

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