Synthesis 1990; 1990(9): 783-784
DOI: 10.1055/s-1990-27014
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A Convenient Lactonization of 2- and 3-Cyclopropylalkanoic Acids to γ- and δ-Lactones

Kotoji Sugahara* , Tsutomu Fujita, Shoji Watanabe, Masami Sakamoto, Ken-ich Sugimoto
  • *Department of Chemistry, Nippon Medical School, Kosugicho, Nakahara, Kawasaki 211, Japan
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Publication History

Publication Date:
17 September 2002 (online)

A convenient preparative method of obtaining 2,2,4,5,5-pentaalkyl-δ- valerolactones 2a-d or 2,2,4,4-tetraalkyl-γ-butyrolactones 4a-e by the acid-catalyzed lactonization of 3-cyclopropylalkanoic acids, and for obtaining bicyclo-γ-lactones 6a-d from bicyclic 2-cyclopropylalkanoic acids 5a-d is presented.

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