Synthesis 1990; 1990(10): 897-899
DOI: 10.1055/s-1990-27047
paper
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Synthesis of β-Hydroxy Esters by Lithium/Ammonia Reduction of α,β-Epoxy Esters

J. L. van der Baan* , J. W. F. K. Barnick, F. Bickelhaupt
  • *Scheikundig Laboratorium, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands
Further Information

Publication History

Publication Date:
17 September 2002 (online)

Aliphatic β-hydroxy esters (alkyl 3-hydroxyalkanoates) are conveniently prepared in high yield by regioselective lithium/ammonia reduction of α,β-epoxy esters (alkyl 2,3-epoxyalkanoates).

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