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Synlett 1991; 1991(8): 573-574
DOI: 10.1055/s-1991-20802
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An Optimized Synthesis of (2S,5S)-2,5-Dimethylpyrrolidine

Takashi Yamazaki* , Rayomand Gimi, John T. Welch
  • *Department of Chemistry, State University of New York at Albany, 1400 Washington Ave., Albany, New York 12222, USA
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Publication Date:
07 March 2002 (online)

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An optimized procedure for the synthesis of the useful chiral auxiliary (2S,5S)-2,5-dimethylpyrrolidine is reported starting form L-alanine. The conditions have been refined so that each step is easily reproduced in greater than 83% yield.

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