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Synthesis 1991; 1991(1): 83-86
DOI: 10.1055/s-1991-26387
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Synthesis of Novel 1,2,4-Triazino[5,6-b]quinoxalines and Their Tri-N-oxides

John K. Gallos* , Nicolaos G. Argyropoulos
  • *Department of Chemistry, Aristotelian University of Thessaloniki, Thessaloniki 54006, Greece
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Publikationsdatum:
17. September 2002 (online)

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Reaction of [1,2,5]oxadiazolo[3,4-b]quinoxaline 1-oxides with stable nitrile oxides in refluxing dichloromethane affords good yields of 1,2,4-triazino [5,6-b]quinoxaline 1,2,4-tri-N-oxides, a novel class of compounds containing the pyrazino[2,3-e]triazine skeleton and also bearing three N-oxides in the same triazine ring. The tri-N-oxides are reduced with triphenylphosphine or sodium dithionite to the corresponding 5,10-dihydro-1,2,4-triazino[5,6-b] quinoxalines, which are converted to 1,2,4-triazino[5,6-b] quinoxalines upon oxidation with iodosobenzene bis(trifluoroacetate).