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Synthesis 1991; 1991(11): 1001-1002
DOI: 10.1055/s-1991-26629
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Synthesis of Isothiocyanates by Reaction of Amides with Carbon Disulfide in the Presence of Solid Potassium Carbonate/Sodium Hydroxide Mixture

Domenico Albanese* , Michele Penso
  • *Centro CNR and Dipartimento di Chimica Organica e Industriale dell'Università, Via Golgi 19, I-20133 Milano, Italy.
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Publication Date:
29 April 2002 (online)

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Readily available N-monosubstituted trifluoroacetamides are transformed into isothiocyanates in good yield by reaction, at room temperature, with carbon disulfide in acetonitrile in the presence of anhydrous sodium hydroxide/potassium carbonate basic mixture.