Download PDF
Synlett 1992; 1992(6): 531-533
DOI: 10.1055/s-1992-21405
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Synthesis of a Novel Serotonin-3 (5-HT3) Receptor Antagonist

Tsuneyuki Sugiura* , Toshiaki Matsui, Hisao Nakai, Masaki Okamoto, Shinsuke Hashimoto, Yoichi Iguchi, Hirohisa Wakatsuka, Masanori Kawamura
  • *Minase Research Institute, Ono Pharmaceutical Co., Ltd., Shimamoto Mishima, Osaka 618, Japan
Further Information

Publication History

Publication Date:
08 March 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

A practical method for the synthesis of ONO-3051 {6-amino-7-chloro-2-[(5-methyl-4-imidazolyl)methyl]isoquinolin-1-(2H)-one (3)}, a highly potent and orally active serotonin-3 (5-HT3) receptor antagonist, was developed. This method includes an efficient synthesis of a key intermediate, 6-amino-7-chloroisoquinolin-1(2H)-one (10).

      >