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Synthesis 1993; 1993(3): 334-342
DOI: 10.1055/s-1993-25861
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One-Pot Preparation of 6-Substituted 3(2H)-Pyridazinones from Ketones

W. J. Coates* , A. Mckillop
  • *SmithKline Beecham Pharmaceuticals, The Frythe, Welwyn, Hertfordshire, AL6 9AR, England
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Publication Date:
17 September 2002 (online)

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A one-pot process for the preparation of 6-phenyl-3(2H)-pyridazinone from acetophenone and glyoxylic acid has been investigated and shown to have wide utility in the preparation of 6- and 5,6-substituted 3(2H)-pyridazinones. Limitations to the process encountered with 2′-hydroxyacetophenone and with basic heteroaromatic ketones have been overcome, and the processes described offer the rapid and efficient synthesis of many 6-substituted pyridazinones from readily available ketones.