Download PDF
Synlett 1994; 1994(1): 57-61
DOI: 10.1055/s-1994-22737
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Ureas as Backbone Replacements for the Phosphodiester Linkage in Oligonucleotides

Adrian Waldner* , Alain De Mesmaeker, Jacques Lebreton, Valérie Fritsch, Romain M. Wolf
  • *Central Research Laboratories, CIBA-GEIGY Ltd., CH-4002 Basel, Switzerland
Further Information

Publication History

Publication Date:
22 March 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

The synthesis of thymidine dimers containing an urea moiety in place of the natural phosphodiester backbone is described. These new dimers were incorporated in oligodeoxyribonucleotides and melting temperatures (Tm) of the DNA/RNA and DNA/DNA duplexes as well as the nuclease resistance of these single strands were determined. In addition, molecular modeling studies are reported.

      >