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Synlett 1994; 1994(8): 601-604
DOI: 10.1055/s-1994-22941
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Synthetic Studies on Oligomycins. Synthesis of the Oligomycin B Polypropionate Portion

Masaya Nakata* , Takashi Ishiyama, Shinichi Akamatsu, Rika Suzuki, Kuniaki Tatsuta
  • *Department of Applied Chemistry, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223, Japan
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18. September 2002 (online)

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The synthesis of the oligomycin B polypropionate (C1-C18) portion was achieved by an aldol coupling between the C3-C9 aldehyde and the C10-C16 ketone. A crotylstannane addition, the Brown's crotylboration, and a metalated methoxyallene addition were the key steps for the syntheses of these subunits.