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Synthesis 1995; 1995(1): 92-96
DOI: 10.1055/s-1995-3844
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Synthesis of Functionalized Acylsilanes from Carboxylic Acid Chlorides and Silyl-Zinc Cyanocuprates

Bianca F. Bonini, Mauro Comes-Franchini, Germana Mazzanti, Umberto Passamonti, Alfredo Ricchi* , Paolo Zani1
  • *Dipartimento di Chimica Organica ”A. Mangini”, Facoltà di Chimica Industriale, Viale Risorgimento 4, I-40136 Bologna, Italy
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Publication Date:
31 December 2000 (online)

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The high yielding synthesis of a variety of acylsilanes, most of them unknown and bearing reactive functionalities, has been accomplished by reaction between carboxylic acid chlorides and a novel silyl-zinc cyanocuprate acting as a silyl anion source. The advantages offered by this procedure with respect to those previously reported, based on carboxylic aced chlorides or on different starting materials, as well as with respect to the use of standard silyl cyanocuprates, are discussed herein.

functionalized acylsilanes - zinc cuprates - nucleophilic silylation - selectivity