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Synthesis 1995; 1995(11): 1423-1426
DOI: 10.1055/s-1995-4117
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A Facile Synthesis of Fragment D of Antibiotic, Nosiheptide

Kazuyuki Umemura, Takashi Tate, Masanori Yamaura, Juji Yoshimura* , Yasuchika Yonezawa, Chung-gi Shin
  • *College of Science and Engineering, Iwaki Meisei University, Iwaki, Fukushima 970, Japan, Fax +81(246)290577
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Publication Date:
31 December 2000 (online)

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A facile synthesis of the N,O-diprotected fragment of D of Nosiheptide, 2-[(1’S,3’S)-1’-amino-3’-carboxy-3’-hydroxypropyl]thiazole-4-carboxylic acid, from (S)-2,2-dimethyl-1,3-dioxalane-4-acetaldehyde in 10 steps and 10.6% overall yield, is described.

antibiotic - nosiheptide - fragment D - chiral synthon - D-glyceraldehyde

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