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Synlett 1995; 1995(8): 845-846
DOI: 10.1055/s-1995-5108
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CsF in Organic Synthesis. Tuning of N- or O-Alkylation of 2-Pyridone

Tsuneo Sato, Koji Yoshimatsu, Junzo Otera*
  • *Department of Applied Chemistry, Okayama University of Science, Ridai-cho, Okayama 700, Japan
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Publication History

Publication Date:
31 December 2000 (online)

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The alkylation of 2-pyridone is effected under mild conditions by CsF: benzyl or allyl chlorides selectively furnishes the N-alkylation product while selective O-alkylation occurs with secondary alkyl iodides.

cesium fluoride - 2-pyridone - N-alkylation - O-alkylation

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