Download PDF
Synlett 1996; 1996(12): 1191-1192
DOI: 10.1055/s-1996-5720
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Et3GeNa Promoted Formation of Trifluoromethyl Anion Species from C6H5SCF3: Effective Nucleophilic Trifluoromethylation of Various Aldehydes

Yasuo Yokoyama* , Kunio Mochida1
  • *Department of Chemistry, Faculty of Science, Gakushuin University 1-5-1 Mejiro, Toshima-ku, Tokyo 171 Japan
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

We developed the effective formation of trifluoromethyl anion species from C6H5SCF3 by use of Et3GeNa. Various substrates, such as, alkyl, aryl and unsaturated aldehydes could be transformed to the corresponding α-trifluoromethylated carbinols in good to excellent yields under this reaction condition. This trifluoromethylation proceeded smoothly by use of only Et3GeNa/C6H5SCF3 combination.

Germyl anion - C6H5SCF3 - Trifluoromethylation - Aldehyde

      >