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Synlett 1997; 1997(SI): 435-436
DOI: 10.1055/s-1997-6124
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An Allosamizoline/Glucosamine Hybrid NAGase Inhibitor

Spencer Knapp1 , Brian A. Kirk2 , David Vocadlo3 , Stephen G. Withers3
  • 1Department of Chemistry, Rutgers - The State University of New Jersey, Taylor Road, Piscataway, New Jersey 08855, USA, Fax: 908 445 5312; E-mail: knapp@rutchem.rutgers.edu
  • 2Department of Chemistry, Rutgers - The State University of New Jersey, Taylor Road, Piscataway, New Jersey 08855, USA
  • 3Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1
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Publication History

Publication Date:
31 December 2000 (online)

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The glucosamine isothiourea derivative 7, which resembles the aminocyclitol isourea portion of the chitinase inhibitor allosamidin (5), inhibits jack bean NAGase with K i=160 μM.

enzyme mechanism - NAGase - chitinase - thiazoline - isothiourea

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