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Synlett 1998; 1998(10): 1144-1146
DOI: 10.1055/s-1998-1876
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New Efficient Conditions for the Reduction with NADH Models

J. L. Vasse* , P. Charpentier, V. Levacher, G. Dupas, G. Quéguiner, J. Bourguignon
  • *INSA-IRCOF, Laboratoire de Chimie Organique Fine et Hétérocyclique, UPRESA 6014, B.P. 08, 76131 Mont St Aignan, France; E-mail: jbourgui@ircof.insa-rouen.fr
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Publication History

Publication Date:
31 December 2000 (online)

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New conditions were used for the efficient reduction of various nitroalkenes and two prochiral ketones by using NADH mimics. The present procedure is very useful since it does not involve magnesium perchlorate which is replaced by magnesium bromide in THF. High conversions were observed. The new conditions were checked in asymmetric reductions.

chemoselective reduction - enantioselective reduction - NADH mimics - catalysis - magnesium salts