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DOI: 10.1055/s-1999-13990
Georg Thieme Verlag Stuttgart · New York
Heparinoids: Structure, Biological Activities and Therapeutic Applications
Publication History
June 29, 1998
December 20, 1998
Publication Date:
31 December 1999 (online)
Abstract:
Heparin is an important polyanionic drug having a wide variety of different biological activities. Substantial research effort has focused on the preparation of improved heparins and heparin analogues that might exhibit higher specificity and decreased side effects. These heparin analogues or heparinoids include sulfated polysaccharides from plant and animal origin, synthetic derivatives of polysaccharides, and acidic oligosaccharides and their small synthetic analogues. The structure, biological activities and therapeutic potential of these heparinoids are discussed.
Key words:
Heparin - heparinoid - glycosaminoglycan - sulfated polysaccharide - therapeutic applications