Heparinoids: Structure, Biological Activities and Therapeutic Applications

Nur Sibel Gunay; Robert J. Linhardt

doi:10.1055/s-1999-13990

Planta Medica, Table of Contents

Planta Med 1999; 65(4): 301-306
DOI: 10.1055/s-1999-13990

Review

Georg Thieme Verlag Stuttgart · New York

Heparinoids: Structure, Biological Activities and Therapeutic Applications

Nur Sibel Gunay, Robert J. Linhardt

Division of Medicinal and Natural Products Chemistry, College of Pharmacy and Department of Chemical and Biochemical Engineering, University of Iowa, Iowa City, Iowa, U.S.A.

Abstract

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Abstract:

Heparin is an important polyanionic drug having a wide variety of different biological activities. Substantial research effort has focused on the preparation of improved heparins and heparin analogues that might exhibit higher specificity and decreased side effects. These heparin analogues or heparinoids include sulfated polysaccharides from plant and animal origin, synthetic derivatives of polysaccharides, and acidic oligosaccharides and their small synthetic analogues. The structure, biological activities and therapeutic potential of these heparinoids are discussed.

Key words:

Heparin - heparinoid - glycosaminoglycan - sulfated polysaccharide - therapeutic applications

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