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Planta Med 1999; 65(6): 558-561
DOI: 10.1055/s-1999-14026
Original Paper

Georg Thieme Verlag Stuttgart · New York

Lignan and Phenylpropanoid Glycosides from Lancea tibetica and Their Antitumor Activity

Baoning Su, Qixiu Zhu, Kun Gao, Chengshan Yuan, Zhongjian Jia
  • Department of Chemistry, National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, People's Republic of China
Further Information

Publication History

November 20, 1998

April 6, 1999

Publication Date:
31 December 1999 (online)

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Abstract

A new lignan glucoside, the first 7,9′-monoepoxytetrahydrofuran type lignan with the cis-relationship of H-7 and H-8, named tibeticoside (1), as well as ten known compounds have been isolated from the medicinal plant (roots, stems and leaves) Lancea tibetica. The structure of tibeticoside ( 1) has been elucidated on the basis of chemical and spectral evidence, especially by 2D-NMR (1H-1H COSY, HMQC, HMBC, NOESY). In addition, sylvatesmin (6) exhibited effective antitumor activity on B16 cells.

Key words:

Lancea tibetica - Scrophulariaceae - lignan glucoside - phenylpropanoid glycosides - tibeticoside - antitumor activity

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