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Synlett 1999; 1999(5): 608-610
DOI: 10.1055/s-1999-2674
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Use of Microwave Irradiation and Solid Acid Catalysts in an Enhanced and Environmentally Friendly Synthesis of Coumarin Derivatives

Antonio de la Hoz* , Andrés Moreno, Ester Vázquez
  • *Dpto. Química Orgánica, Facultad de Química, Universidad de Castilla-La Mancha, Campus Universitario, Ciudad Real 13071, Spain; Fax +3 49 26 29 53 18
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Publication Date:
31 December 1999 (online)

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Condensation of phenol, 1,3-dihydroxybenzene and 1,3,5-trihydroxybenzene with propynoic and propenoic acids and ethyl acetoacetate using solid acid catalysts and microwave irradiation produces coumarins in excellent yields. The use of hterogeneous catalystas eliminates the production of acidic waste streams associated with conventional (Lewis) acid catalysts. This quick, efficient and environmentally friendly procedure permits the synthesis of substituted coumarins as well as coumarins without 4-alkyl substituents, which are the most difficult to synthesize.

phenols - α,β-unsaturated carboxylic acids - solid acid catalyst - microwave - coumarin derivatives