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Synlett 1999; 1999(11): 1763-1765
DOI: 10.1055/s-1999-2943
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Thionyl Chloride-Benzotriazole in Methylene Chloride: A Convenient Solution for Conversion of Alcohols and Carboxylic Acids Expeditiously into Alkyl Chlorides and Acid Chlorides by Simple Titration

Sachin S. Chaudhari* , Krishnacharya G. Akamanchi
  • *Pharmaceuticals and Fine Chemicals Division, Department of Chemical Technology, University of Mumbai, Matunga, Mumbai-400 019, India; Fax (91) 22 4 14 56 14; E-mail: kga@udct.ernet.in
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Publikationsdatum:
31. Dezember 1999 (online)

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A solution of 1 : 1 equivalent of thionyl chloride and benzotriazole in dry methylene chloride efficiently transforms alcohols and carboxylic acids into the corresponding alkyl chlorides and acid chlorides respectively at room temperature, with excellent yields by simple titration.

benzotriazole - thionyl chloride - chlorination - alcohols - carboxylic acids