Download PDF
Synthesis 2000; 2000(13): 1814-1816
DOI: 10.1055/s-2000-8237
short paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

New One-Step Synthesis of 2-Aryl-1H-Imidazoles: Dehydrogenation of 2-Aryl-Δ2-Imidazolines with Dimethylsulfoxide

Maria Anastassiadou* , Geneviève Baziard-Mouysset, Marc Payard
  • *Laboratoire de Chimie Pharmaceutique, Faculté de Pharmacie, Université Paul Sabatier. 35, Chemin des Maraîchers, 31062 Toulouse Cedex 4, France; Fax (33)5 62 25 68 81; E-mail: chimphar@cict.fr
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

A new one-step method for the preparation of 2-aryl-1H-imidazoles 3, based on the DMSO dehydrogenation of 2-aryl-Δ2-imidazolines, is described. A comparative study between DMSO and 10% Pd/C, the best known catalyst employed in this transformation, has also been developed. Both protocols were carried out at 120°C for 48 hours.

oxidation - dehydrogenation - Δ2-imidazoline - 1H-imidazole - DMSO - Pd/C

      >