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Planta Med 2000; 66(5): 439-443
DOI: 10.1055/s-2000-8582
Original Paper
Georg Thieme Verlag Stuttgart · New York

Effect of Honey on Naringin Absorption from a Decoction of the Pericarps of Citrus grandis

Yu-Chi Hou1 , Su-Lan Hsiu2 , Hsiu-Fang Yen2 , Chung-Chuan Chen1 , Pei-Dawn Lee Chao2,*
  • 1 Graduate Institute of Chinese Pharmaceutical Sciences, Taichung, Taiwan, R.O.C.
  • 2 Department of Pharmacy, China Medical College, Taichung, Taiwan, R.O.C.
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Publication History

Publication Date:
31 December 2000 (online)

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Abstract

To measure naringin/naringenin absorption of a decoction prepared from the pericarps of Citrus grandis and to investigate the effect of honey on naringin/naringenin absorption, six healthy males received 200 mL decoctions of untreated and honey-treated Pericarpium Citri Grandis in a randomized crossover design. The absorption was measured by renal recovery of naringenin glucuronides/sulfates over 48 hours. The contents of naringin/naringenin in 200 mL decoctions of untreated and honey-treated Pericarpium Citri Grandis were determined to be 261.5/23.8 μmol and 303.3/11.6 μmol, respectively. The mean cumulated renal excretion of naringenin glucuronides/sulfates after intake of these two decoctions were 74.8 μmol (26.2 % of dose) and 49.8 μmol (15.8 % of dose), respectively. Paired Student’s t-test showed that the difference of the total renal recovery of naringin/naringenin between the two decoctions was significant. The results indicated that honey significantly reduced naringin/naringenin absorption by 33.4 % in humans and suggested that honey treatment might alter the efficacy of Pericarpium Citri Grandis.

Key words

Honey - naringin - naringenin - absorption - Citrus grandis - Rutaceae

References

  • 1 Zhong-go Yi-Xue Ke Xue Xue-Yuan Yao wu Yan-Jiu-suo.. Zhong-yao Zhi (III). 1st ed. Bei-jing:; Ren-min Wei-sheng Chu-ban-she, 1984: 66-71
  • 2 Hou  Y C,, Hsiu  S L,, Chen  C C,, Chao  P DL.. Determination and comparison of naringin and naringenin concentrations among water extracts of various processed Citri grandis pericarpium.  Chin. Pharm. J.. 1998;;  50 137-45
    PubMedSearch in Google Scholar
  • 3 Martin  M J,, Marhuenda  E,, Perez-Guerrero  C,, France  J M.. Antiulcer effect of naringin on gastric lesions induced by ethanol in rats.  Pharmacology. 1994;;  49 144-50
    PubMedSearch in Google Scholar
  • 4 Kroyer  G.. The antioxidant activity of Citrus fruit peels.  Z. Ernährungswiss.. 1986;;  25 63-9
    PubMedSearch in Google Scholar
  • 5 Parmar  N S.. The gastric anti-ulcer activity of naringenin, a specific histidine decarboxylase inhibitor.  Int. J. Tissue React.. 1983;;  5 415-20
    PubMedSearch in Google Scholar
  • 6 de Rojas  V R,, Somoza  S B,, Ortega  T,, Villar  A.. Vasodilatory effect of naringenin in rat aorta.  Phytother. Res.. 1996;;  10 (s1.1) s123-5
    PubMedSearch in Google Scholar
  • 7 So  F V,, Guthrie  N,, Chambers  A F,, Moussa  M,, Carroll  K K.. Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and Citrus juices.  Nutr. Cancer. 1996;;  26 167-81
    PubMedSearch in Google Scholar
  • 8 Guengerich  F P,, Kim  H D.. In vitro inhibition of dihydropyridine oxidation and aflatoxin B1 activation in human liver microsomes by naringenin and other flavonoids.  Carcinogenesis. 1990;;  11 2275-9
    PubMedSearch in Google Scholar
  • 9 Ameer  B,, Weintraub  R A.. Drug interactions with grapefruit juice.  Clin. Pharmacokinet.. 1997;;  33 103-21
    PubMedSearch in Google Scholar
  • 10 Bailey  D G,, Arnold  J M,, Spence  J D.. Grapefruit juice and drugs, how significant is the interaction?.  Clin. Pharmacokinet.. 1994;;  26 91-8
    PubMedSearch in Google Scholar
  • 11 Edwards  D J,, Bellevue  F H 3rd,, Woster  P M.. Identification of 6′,7′-dihydroxybergamottin, a cytochrome P450 inhibitor, in grapefruit juice.  Drug Metab. Disp.. 1996;;  24 1287-90
    PubMedSearch in Google Scholar
  • 12 Edwards  D J,, Bernier  S M.. Naringin and naringenin are not the primary CYP3A inhibitors in grapefruit juice.  Life Sci.. 1996;;  59 1025-30
    CrossrefPubMedSearch in Google Scholar
  • 13 Schmiedlin-Ren  P,, Edwards  D J,, Fitzsimmons  M E,, He  K,, Lown  K S,, Woster  P M,, Rahman  A, et al.. Mechanism of enhanced oral availability of CYP 3A4 substrates by grapefruit constituents.  Drug Metab. Disp.. 1997,;  25 1228-33
    PubMedSearch in Google Scholar
  • 14 Bailey  D G,, Kreeft  J H,, Munoz  C,, Freeman  D J,, Bend  J R.. Grapefruit juice-felodipine interaction: Effect of naringin and 6′,7′-dihydroxybergamottin in human.  Clin. Pharmacol. Ther.. 1998;;  64 248-56
    CrossrefPubMedSearch in Google Scholar
  • 15 He  K,, Iyer  K R,, Hayes  R N,, Sinz  M W,, Wolf  T F,, Hollenberg  P F.. Inactivation of cytochrome P450 3A4 by bergamottin, a component of grapefruit juice.  Chem. Res. Toxicol.. 1998;;  11 252-59
    CrossrefPubMedSearch in Google Scholar
  • 16 Zhong-Hua Ren-Min Gong-He Guo Wei-sheng-bu Yao-dian Wei-yuan-hui.. Zhong-Hua Ren-Min Gong-He Guo Yao-dien Di-yi-bu Fu-lu. 1st ed. Bei-jing:; Ren-min Wei-sheng Chu-ban-she, 1990: 5-7
  • 17 Zhong-yao Ci-hai Bian-shen Wei-yuan-hui.. Zhong-yao Ci-hai. 1st ed. Bei-jing:; Zhong-guo Yi-yao Ke-ji Chu-ban-she, 1993: 1171-2
  • 18 Fuhr  U,, Kummert  A L.. The fate of naringin in humans: A key to grapefruit juice-drug interactions?.  Clin. Pharmacol. Ther.. 1995;;  58 365-73
    CrossrefPubMedSearch in Google Scholar
  • 19 Ishii  K,, Furuta  T,, Kasuya  Y.. Determination of naringin in human urine by high-performance liquid chromatography utilizing solid-phase extraction.  J. Chromatogr. B.. 1997;;  704 299-305
    PubMedSearch in Google Scholar
  • 20 Patel  M,, Tang  B K,, Kalow  W.. Variability of acetaminophen metabolism in Caucasians and Orientals.  Pharmacogenetics. 1992;;  2 38-45
    PubMedSearch in Google Scholar
  • 21 Ameer  B,, Weintraub  R A,, Johnson  J V,, Yost  R A,, Rouseff  R L.. Flavanone absorption after naringin, hesperidine and Citrus administration.  Clin. Pharmacol. Ther.. 1996;;  60 34-40
    CrossrefPubMedSearch in Google Scholar
  • 22 Bokkenheuser  V D,, Shackleton  C H,, Winter  L J.. Hydrolysis of dietary flavonoid glycosides by strains of intestinal bacteroides from humans.  Biochem. J.. 1987;;  248 953-6
    PubMedSearch in Google Scholar

Prof. Pei-Dawn Lee Chao

Department of Pharmacy China Medical College

Taichung

Taiwan 404

R. O. C.

Email: pdlee@mail.cmc.edu.tw

Phone: 886-4-2033108