Planta Med 2000; 66(8): 694-698
DOI: 10.1055/s-2000-9775
Original Paper
© Georg Thieme Verlag Stuttgart · New York

Anti-Hepatitis B Virus Effects of Wogonin Isolated from Scutellaria baicalensis

Ray-Ling Huang1,*, Chien-Chih Chen1 , Huey-Lan Huang2 , Chung-Gwo Chang3 , Chieh-Fu Chen1 , Chungming Chang2 , Ming-Tsuen Hsieh3
  • 1 Department of Pharmacology, National Research Institute of Chinese Medicine, Taipei, Taiwan, R.O.C.
  • 2 Institute of Microbiology and Immunology, National Yang-Ming University, Taiwan, R.O.C.
  • 3 Department of Chinese Medicine, China Medical College, Taichung, Taiwan, R.O.C.
Further Information

Publication History

Publication Date:
31 December 2000 (online)


By using an HBV-producing cell line (MS-G2) in vitro culture system, we found that wogonin isolated from Scutellaria baicalensis can suppress HBV surface antigen production (P < 0.001) without evidence of cytotoxicity. By assaying the endogenous HBV DNA polymerase activity, we found that both the relaxed circular and the linear forms of HBV DNA are significantly reduced in the wogonin-treated group. Wogonin deserves to be further evaluated for the treatment of human HBV infection.


Dr. Ray-Ling Huang

Department of Pharmacology National Research Institute of Chinese Medicine

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