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Synthesis 2001(6): 0919-0923
DOI: 10.1055/s-2001-13416
DOI: 10.1055/s-2001-13416
PAPER
© Georg Thieme Verlag Stuttgart · New York
The First Intramolecular Friedel-Crafts Reaction of Baylis-Hillman Adducts: Synthesis of Functionalized Indene and Indane Derivatives
Further Information
Received
2 November 2000
Publication Date:
15 October 2004 (online)
Publication History
Publication Date:
15 October 2004 (online)
Abstract
The first intramolecular Friedel-Crafts reaction of the Baylis-Hillman adducts using P2O5 leading to the formation of functionalized indene derivatives and subsequent hydrogenation providing indane derivatives have been described.
Key words
Baylis-Hillman reaction - intramolecular Friedel-Crafts reaction - indenes - indanes - DABCO - phosphorus pentoxide
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References
Other reagents, e. g., p-TsOH and TiCl4 provided the required indene derivative in trace amounts only.