N-Arylation of 1,4,7,10-Tetraazacyclododecanes

Michael Subat; Burkhard König

doi:10.1055/s-2001-17531

PAPER

N-Arylation of 1,4,7,10-Tetraazacyclododecanes

Michael Subat, Burkhard König*
Institut für Organische Chemie, Universität Regensburg, 93040 Regensburg, Germany
Fax: +49(941)5431717; e-Mail: burkhard.koenig@chemie.uniregensburg.de;

Abstract

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Abstract

Palladium-catalyzed N-arylation reactions provide acces to N-aryl-substituted and N-aryl-bridged 1,4,7,10-tetraazacyclododecanes. Yields of arylation products are low with simple haloarenes, whereas reactions with pyridine derivatives give substituted cyclens in moderate to satisfactory yields.

Keywords

azamacrocycle - palladium - N-arylation

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