A facile one-pot synthesis of 1,3-diketones with stereogenic quaternary center at
C-2 has been developed on the basis of an oxidative-rearrangement of a series of tertiary
α-hydroxy epoxides on treatment with pyridinium chlorochromate (PCC). A possible mechanism
is also discussed.
1,3-diketones - quaternary carbon - pyridinium chlorochromate - tertiary α-hydroxy
epoxides - oxidative rearrangement