Abstract
Assay-guided fractionation of the EtOAc soluble fraction of the rhizomes of Curcuma longa furnished three DPPH free radical scavenging diarylheptanoids, curcumin (1), demethoxycurcumin (2), and bisdemethoxycurcumin (3). Compounds 1 - 3 showed the DPPH radical scavenging effects with IC50 values of 2.8, 39.2, 308.7 μM, respectively. L-Ascorbic acid and resveratrol as positive
controls exhibited IC50 values of 22.5 and 25.0 μM, respectively. Compounds 1 - 3 showed significant hepatoprotective effects on tacrine-induced cytotoxicity in human
liver-derived Hep G2 cells. The EC50 values of 1 - 3 are 86.9, 70.7, and 50.2 μM, respectively. Silybin (EC50 = 69.0 μM) and silychristin (EC50 = 82.7 μM) were used as positive controls.
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Prof. Dr. Youn-Chul Kim
MRRC and College of Pharmacy
Wonkwang University
Iksan 570-749
South Korea
Email: yckim@wonkwang.ac.kr
Fax: +82-63-852-8837
