Traceless Linking of Pyrroles: General Methology and Solid Phase Supported Functionalizations

Abstract

Transacetalization reaction of the diethoxymethyl (DEM) protected pyrroles 2a-f with the diol functionalized resin 3 resulted in the formation of the immobilized pyrroles 4a-f. Regioselective transformations including Pd-catalyzed coupling reactions and reductive aminations on solid phase were demonstrated.

Key words

solid-phase synthesis - traceless linker - pyrroles - palladium - DEM-protection

References

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Bergauer, M.; Gmeiner, P. Synthesis 2001, 2281.