Palladium-Catalysed Cross-Coupling of Iodovinylic Acids with Organometallic Reagents. Selective Synthesis of 3,3-Disubstituted Prop-2-enoic Acids

Mohamed Abarbri; Jérôme Thibonnet; Jean-Luc Parrain; Alain Duchêne

doi:10.1055/s-2002-20971

PAPER

Palladium-Catalysed Cross-Coupling of Iodovinylic Acids with Organometallic Reagents. Selective Synthesis of 3,3-Disubstituted Prop-2-enoic Acids

Mohamed Abarbri^a, Jérôme Thibonnet^a, Jean-Luc Parrain^b, Alain Duchêne*^a
^a Laboratoire de Physicochimie des Interfaces et des Milieux Réactionnels, Faculté des Sciences de Tours, Parc de Grandmont, 37200 Tours, France
Fax: +33(2)47366960; e-Mail: duchene@delphi.phys.univ-tours.fr;
^b Laboratoire de Synthèse Organique UMR 6009 CNRS, Case postale D120, Faculté des Sciences de Saint Jérôme, Avenue Escadrille Normandie-Niemen, F.13397 Marseille Cedex 20, France
Fax: +33(4)91983865; e-Mail: jl.parrain@lso.u-3mrs.fr;

Abstract

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Abstract

3,3-Disubstituted prop-2-enoic acids were selectively prepared in good yields under mild experimental conditions via palladium-catalysed cross-coupling of 3-substituted 3-iodobut-2-enoic acids with miscellaneous organometallic reagents using dichlorobis(acetonitrile)palladium(II) as catalyst and DMF as solvent.

Key words

coupling reactions - carboxylic acids - organozinc reagents - organotin reagents - palladium catalyst

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References

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