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Synthesis 2002(6): 0753-0756
DOI: 10.1055/s-2002-25772
PAPER
© Georg Thieme Verlag Stuttgart · New York

Synthesis of New Ethyl 3-Amino-4-arylfuran-2-carboxylates

Vincent Lisowski, Duc Nghia Vu, Xiao Feng, Sylvain Rault*
Centre d’Etudes et de Recherche sur le Médicament de Normandie, UFR des Sciences Pharmaceutiques, 1, rue Vaubénard, 14032 Caen Cedex France
Fax: +33(2)31931188; e-Mail: rault@pharmacie.unicaen.fr;
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Publication History

Received 21 November 2001
Publication Date:
26 April 2002 (online)

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Abstract

An efficient method for the preparation of new ethyl 3-amino-4-arylfuran-2-carboxylates is described. The synthesis proceeds via the corresponding hydroxyacrylonitrile sodium salt and an intermediate malonate vinyl ether. The last step of ring closure afforded the ethyl 3-amino-4-arylfuran-2-carboxylates in 15% to 40% yields.

Key words

furans - amino esters - ring closure