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Planta Med 2002; 68(4): 289-296
DOI: 10.1055/s-2002-26761
DOI: 10.1055/s-2002-26761
Review
© Georg Thieme Verlag Stuttgart · New YorkOxidative Stress, Plant-Derived Antioxidants and Liver Fibrosis
Further Information
Publication History
July 31, 2001
January 6, 2002
Publication Date:
02 May 2002 (online)
Abstract
There is accumulating evidence that oxidative stress plays a considerable role in the development of liver fibrosis by acting in different cell types and in different signaling pathways. Consequently, antioxidants, particularly those of plant origin, have emerged as potent antifibrotic agents. This review briefly summarizes current views of the mechanisms of fibrogenesis and recent findings on the antifibrotic potential of plant-derived antioxidants.
Key words
Antioxidants - fibrogenesis - flavonoids - hepatic stellate cells - reactive oxygen species
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Prof. Dr. Rolf Gebhardt
University of Leipzig
Medical Faculty
Institute of Biochemistry
Liebigstr. 16
04103 Leipzig
Germany
Fax: +49-341-9722109
Email: rgebhardt@medizin.uni-leipzig.de