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Synthesis 2002(7): 0916-0920
DOI: 10.1055/s-2002-28518
PAPER
© Georg Thieme Verlag Stuttgart · New York

Reaction of (Alkylthio)chloroacetylenes with Thiosemicarbazones: A Route to Functionalized Thiazoles

Svetlana G. D’yachkova*, Elena A. Nikitina, Ludmila I. Larina, Peter E. Ushakov, Nina K. Gusarova, Lidiya M. Sinegovskaya, Boris A. Trofimov
A. E. Favorsky Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 664033 Irkutsk, Russia
Fax: +7(395)2396046; e-Mail: dsg@irioch.irk.ru;
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Publication History

Received 24 January 2002
Publication Date:
14 May 2002 (online)

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Abstract

(Alkylthio)chloroacetylenes 1 react with thiosemicarbazones 2 at room temperature in a medium of aliphatic ketone to form hydrochlorides of 2-alkanone-N-[4-(organylthio)-1,3-thiazol-2-yl]hydrazones 3 in yields of up to 65%.

Key words

(alkylthio)chloroacetylenes - thiosemicarbazones - hydrochlorides of 2-alkanone-N-[4-(organylthio)-1,3-thiazol-2-yl]hydrazones - 2-alkanon-N-[4-(organylthio)-1,3-thiazol-2-yl]hydra-zones - synthesis

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