Synthesis 2002(10): 1379-1384
DOI: 10.1055/s-2002-33106
PAPER
© Georg Thieme Verlag Stuttgart · New York

A Facile Access to 2-CF3-Imidazo[1,2-a]pyridines

Arcady L. Krasovsky, Valentine G. Nenajdenko*, Elizabeth S. Balenkova
Department of Chemistry, Moscow State University, 119899 Moscow, Russia
Fax: +7(095)9328846; e-Mail: Nen@acylium.chem.msu.ru;
Further Information

Publication History

Received 10 April 2001
Publication Date:
01 August 2002 (online)

Abstract

A new simple and efficient way to 2-CF3-imidazo[1,2-a]pyridines and 2-CF3-imidazo[1,2-a]quinolines by the reaction of 1,1,1-trifluoro-4-(phenylsulfonyl)but-3-ene-2,2-diols 1a,b with various 2-aminopyridines is described. The cyclization reaction proceeds diastereospecifically under mild conditions in water.