Conversion of Epoxides to Halohydrins with Elemental Halogen Catalyzed by Phenylhydrazine

Abstract

The highly regioselective method for the synthesis of β-iodohydrins and β-bromohydrins by the direct ring opening of 1,2-epoxides with elemental halogen in the presence of phenylhydrazine is described. This method occurs under neutral and mild conditions with high yields in various aprotic solvents even when sensitive functional groups are present.

Key word

phenylhydrazine - epoxide - halohydrins

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