Synthesis 2002(14): 2096-2104
DOI: 10.1055/s-2002-34379
PAPER
© Georg Thieme Verlag Stuttgart · New York

Determination of the Relative Configuration of the C-2-C-1′-Fragment of Cytostatin­

Laurent Bialya, Meritxell Lopez-Caneta, Herbert Waldmann*a,b
a Max-Planck-Institut für molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Str. 11, 44227 Dortmund
b Universität Dortmund, Fachbereich 3, Organische Chemie, 44221 Dortmund
Fax: +49(231)1332499; e-Mail: herbert.waldmann@mpi-dortmund.mpg.de;
Further Information

Publication History

Received 6 June 2002
Publication Date:
26 September 2002 (online)

Abstract

Four diastereomers of a simple subtructure of cytostatin containing the α,β-unsaturated lactone subunit were synthesized and their NMR-spectroscopical data were compared with values recorded for the natural product in order to unravel the relative stereochemistry in cytostatin.