Synthesis of 1,4-Oxazepin-7-ones Using Baylis-Hillman Products as Key Intermediates­

Abstract

Baylis-Hilman adducts derived from aromatic aldehydes and methyl acrylate can be readily converted to 1,4-oxazepin-7-ones substituted in 2-, 3-, or 4-position by condensation with amino alcohols.

Baylis-Hillman reaction - 1,4-oxazepin-7-ones - amino alcohols - aromatic aldehydes - lactonization - hydrogenation

References

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