Yb(OTf)3-Catalyzed One-Pot Synthesis of Quinazolin-4(3H)-ones from Anthranilic­ Acid, Amines and Ortho Esters (or Formic Acid) in Solvent-Free Conditions

Limin Wang; Jianjun Xia; Fang Qin; Changtao Qian; Jie Sun

doi:10.1055/s-2003-39397

PAPER

Yb(OTf)₃-Catalyzed One-Pot Synthesis of Quinazolin-4(3H)-ones from Anthranilic Acid, Amines and Ortho Esters (or Formic Acid) in Solvent-Free Conditions

Limin Wang*^a, Jianjun Xia^a, Fang Qin^a, Changtao Qian^b, Jie Sun^b
^a Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Lu, Shanghai 200237, P. R. China
Fax: +86(21)64252288; e-Mail: wanglimin@ecust.edu.cn, wcathy@china.com;
^b Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, P. R. China

Abstract

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Abstract

An efficient synthesis of an array of quinazolin-4(3H)-ones from anthranilic acid, ortho esters (or formic acid) and amines using Yb(OTf)₃ in one-pot under solvent-free conditions is described. Compared with the classical reaction conditions, this new synthetic method has the advantage of excellent yields (75-99%), shorter reaction time (few minutes) and reusability of the catalyst.

Key words

quinazolin-4(3H)-ones - ytterbium triflate - one-pot reaction - anthranilic acid - amine

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References

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Yb(OTf)3-Catalyzed One-Pot Synthesis of Quinazolin-4(3H)-ones from Anthranilic­ Acid, Amines and Ortho Esters (or Formic Acid) in Solvent-Free Conditions

Yb(OTf)₃-Catalyzed One-Pot Synthesis of Quinazolin-4(3H)-ones from Anthranilic Acid, Amines and Ortho Esters (or Formic Acid) in Solvent-Free Conditions