Microwave-Assisted One-Pot Synthesis of 2,4-Disubstituted Quinolines under Solvent-Free Conditions

J. S. Yadav; B. V. S. Reddy; R. Srinivasa Rao; V. Naveenkumar; K. Nagaiah

doi:10.1055/s-2003-40531

PAPER

Microwave-Assisted One-Pot Synthesis of 2,4-Disubstituted Quinolines under Solvent-Free Conditions

J. S. Yadav*, B. V. S. Reddy, R. Srinivasa Rao, V. Naveenkumar, K. Nagaiah
Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad-500 007, India
Fax: +91(40)27160512; e-Mail: yadav@iict.ap.nic.in;

Abstract

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Abstract

Aromatic imines derived in situ from aryl aldehydes and aryl amines undergo smoothly, cyclization with alkynes on the surface of montmorillonite clay impregnated with copper(I) bromide under solvent-free conditions to produce 2,4-disubstituted quinolines in high yields with excellent selectivity. The reaction rates and yields are significantly improved by employing microwave irradiation.

Key words

microwave - aryl imines - alkynes - substituted quinolines

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