Vanadium(III) Chloride-Catalyzed Preparation of β-Amino Alcohols from Epoxides

Gowravaram Sabitha; G. S. Kiran Kumar Reddy; K. Bhaskar Reddy; J. S. Yadav

doi:10.1055/s-2003-41070

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Synthesis 2003(15): 2298-2300
DOI: 10.1055/s-2003-41070

SHORTPAPER

Vanadium(III) Chloride-Catalyzed Preparation of β-Amino Alcohols from Epoxides

Gowravaram Sabitha*, G. S. Kiran Kumar Reddy, K. Bhaskar Reddy, J. S. Yadav
Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad-500 007, India
Fax: +91(40)27160512; e-Mail: sabitha@iict.ap.nic.in;

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Publication History

Received 26 May 2003
Publication Date:
25 September 2003 (online)

Abstract
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Abstract

Vanadium(III) chloride was found to catalyze the cleavage of epoxides with aromatic amines in an efficient way to afford the corresponding β-amino alcohols in very good yields. The reactions are completely anti-stereoselective, highly regioselective and proceed at room temperature.

Key words

epoxides - amines - VCl₃ - amino alcohols

References

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