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Synthesis 2003(18): 2877-2881
DOI: 10.1055/s-2003-42485
DOI: 10.1055/s-2003-42485
PAPER
© Georg Thieme Verlag Stuttgart · New York
Zinc Mediated Friedel-Crafts Acylation in Solvent-Free Conditions under Microwave Irradiation
Further Information
Received
17 September 2003
Publication Date:
17 November 2003 (online)
Publication History
Publication Date:
17 November 2003 (online)
Abstract
Zn powder is found to catalyze the Friedel-Crafts acylation of aromatic compounds with acyl halides efficiently under microwave irradiation in solvent-free conditions. Activated substrates undergo acylation predominantly at the para-position. The Zn powder can be re-used up to six times after simple washing with diethyl ether and dilute HCl.
Key words
Friedel-Crafts acylation - zinc powder - aromatic compounds - solvent-free conditions - microwave activation
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