Identification of an Anti-Inflammatory Principle from the Stem Bark of Millettia versicolor

Maurice Tagatsing Fotsing; Emmanuel Yankep; Dieudonné Njamen; Z. Tanee Fomum; Barthelemy Nyasse; B. Bodo; M. Carmen Recio; Rosa M. Giner; José-Luis Ríos

doi:10.1055/s-2003-42794

Planta Med 2003; 69(8): 767-770
DOI: 10.1055/s-2003-42794

Letter

Identification of an Anti-Inflammatory Principle from the Stem Bark of Millettia versicolor

Maurice Tagatsing Fotsing¹ , Emmanuel Yankep¹ , Dieudonné Njamen² , Z. Tanee Fomum¹ , Barthelemy Nyasse¹ , B. Bodo³ , M. Carmen Recio⁴ , Rosa M. Giner⁴ , José-Luis Ríos⁴

¹Department of Organic Chemistry, University of Yaounde 1, Yaounde, Cameroon
²Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde 1, Yaounde, Cameroon
³Laboratoire de Chimie U.RA. 401, CNRS, Museum National d'Histoire Naturelle, Paris, France
⁴Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Burjassot (Valencia), Spain

Part 12 of the series Milletia of Cameroon

Abstract

The dichloromethane-soluble fraction of the methanol extract of the stem bark of Millettia versicolor Welw. (Leguminosae) has been shown to possess anti-inflammatory activity. The chromatographic fractionation and subsequent analysis of the spectroscopic data of this extract led to the isolation and identification of 2-acetyl-7-methoxynaphtho[2,3-b]furan-4,9-quinone (1) along with two known quinones. Pharmacological data demonstrate that compound 1 has relevant anti-inflammatory properties whereas the other two isolated compounds do not.

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References

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J. L. Ríos

Departament de Farmacologia

Facultat de Farmàcia

Universitat de València

Vicent Andrés Estellés s/n

46100 Burjassot (Valencia)

Spain

Phone: /Fax: +34-963-544-973

Email: riosjl@uv.es