Synthesis 2004(3): 429-435  
DOI: 10.1055/s-2004-815949
© Georg Thieme Verlag Stuttgart · New York

Syntheses of Some 4-Anilinoquinazoline Derivatives

Silvana A. Rocco, José Eduardo Barbarini, Roberto Rittner*
Physical Organic Chemistry Laboratory, , Instituto de Química, UNICAMP, C. P. 6154, 13084-971-Campinas, SP, Brazil
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Further Information

Publication History

Received 9 October 2003
Publication Date:
03 February 2004 (online)


Some 4-N-(3′- or 4′-substituted-phenyl)amino-6,7-dimethoxyquinazolines and the corresponding unsubstituted compounds were synthesized from 2-amino-4,5-dimethoxybenzoic acid and the appropriate substituted anilines. Other related quinazolines or their synthetic intermediates were also obtained. A large number of the described quinazolines are new compounds, while the remaining were prepared by a more efficient procedure. The main goal for the synthesis of these compounds comes from the fact that the 4-anilinoquinazoline pharmacophore is an important unit, which is found among the ATP-competitive inhibitors of several protein kinase enzymes.


Franchini, K., Faculty of Medical Sciences, State University of Campinas, personal communication.