Synthesis 2004(13): 2091-2093  
DOI: 10.1055/s-2004-829170
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York

Iodine Catalyzed One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones and Thiones: A Simple and Efficient Procedure for the Biginelli Reaction [1]

K. V. N. S. Srinivas, Biswanath Das*
Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad-500 007, India
Fax: +91(40)27160512; e-Mail: biswanathdas@yahoo.com;
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Publikationsverlauf

Received 14 April 2004
Publikationsdatum:
27. Juli 2004 (online)

Abstract

Iodine efficiently catalyzes the Biginelli reaction. This procedure involves a one-pot three-component cyclocondensation of aldehydes, 1,3-dicarbonyl compounds and urea or thiourea to afford the corresponding 3,4-dihydropyrimidin-2(1H)-ones or thiones in high yields.