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Synthesis 2005(4): 668-672
DOI: 10.1055/s-2004-831211
DOI: 10.1055/s-2004-831211
PSP
© Georg Thieme Verlag Stuttgart · New York
Chemoselective Deprotection of Allylic Amines Catalyzed by Grubbs’ Carbene
Further Information
Received
5 May 2004
Publication Date:
21 October 2004 (online)
Publication History
Publication Date:
21 October 2004 (online)
Abstract
A commercially available ruthenium complex (first generation Grubbs’ carbene) was used for the catalytic deprotection of allylic amines (secondary as well as tertiary), by using for the first time reagents different from palladium catalysts. Interestingly, the catalytic system directs the reaction toward the selective deprotection of allylamines in the presence of allylic ethers.
Key words
amines - carbenes - catalytic cleavage - protecting groups - ruthenium
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1b
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